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Article

Function of the Drosophila TGF-alpha homolog Spitz is controlled by Star and interacts directly with Star.

Mechanisms of development - 1 Sept 2001

Hsiung F, Griffis E R, Pickup A, Powers M A, Moses K

Abstract excerpt

Drosophila Spitz is a homolog of transforming growth factor alpha (TGF-alpha) and is an activating ligand for the EGF receptor (Egfr). It has been shown that Star is required for Spitz activity. Here we show that Star is quantitatively limiting for Spitz production during eye development. We also show that Star and Spitz proteins colocalize in Spitz sending cells and that this association is not coincident with...

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Source

Identifiers

PMID: 11520660
DOI: 10.1016/s0925-4773(01)00432-4

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Function of the Drosophila TGF-alpha homolog Spitz is controlled by Star and interacts directly with Star.PMID 11520660Read ↗

spitz, a Drosophila homolog of transforming growth factor-alpha, is required in the founding photoreceptor cells of the compound eye facets.Semantic proximity Read ↗

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