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Article

Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila.

Developmental cell - 1 Oct 2004

Schlesinger Ayelet, Kiger Amy, Perrimon Norbert, Shilo Ben-Zion

Abstract excerpt

The Drosophila EGF receptor ligand Spitz is cleaved by Rhomboid to generate an active secreted molecule. Surprisingly, when a cleaved variant of Spitz (cSpi) was expressed, it accumulated in the ER, both in embryos and in cell culture. A cell-based RNAi screen for loss-of-function phenotypes that alleviate ER accumulation of cSpi identified several genes, including the small wing (sl) gene encoding a PLCgamma. sl...

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Source

Identifiers

PMID: 15469842
DOI: 10.1016/j.devcel.2004.09.001

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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