Article
optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila.
Developmental biology - 1 Sept 2013
Li Yumei, Jiang Yuwei, Chen Yiyun, Karandikar Umesh, Hoffman Kristi, Chattopadhyay Abanti, Mardon Graeme, Chen Rui
Abstract excerpt
optix, the Drosophila ortholog of the SIX3/6 gene family in vertebrate, encodes a homeodomain protein with a SIX protein-protein interaction domain. In vertebrates, Six3/6 genes are required for normal eye as well as brain development. However, the normal function of optix in Drosophila remains unknown due to lack of loss-of-function mutation. Previous studies suggest that optix is likely to play an important...
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