Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

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Article

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

Oncogene - 5 Jan 1995

Eshleman J R, Lang E Z, Bowerfind G K, Parsons R, Vogelstein B, Willson J K, Veigl M L, Sedwick W D, Markowitz S D

Abstract excerpt

Hereditary Non-Polyposis Colon Cancer (HNPCC) tumors and some sporadic colon cancers acquire somatic changes in the length of microsatellite sequences. We hypothesized that this 'replication error' (RER) phenotype in these cancers reflects a more general defect which should result in hypermutabil...

Topics

Cell Division
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA, Neoplasm
DNA, Satellite
Humans
Hypoxanthine Phosphoribosyltransferase
Mutation
Thioguanine
Tumor Cells, Cultured

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Open in PubMed

Identifiers

PMID: 7824277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7824277-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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