Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability.

Oncogene - 4 Apr 1996

Eshleman J R, Markowitz S D, Donover P S, Lang E Z, Lutterbaugh J D, Li G M, Longley M, Modrich P, Veigl M L, Sedwick W D

Abstract excerpt

Colon cancer and an increasing number of other cancers have been found to exhibit instability of DNA microsatellite sequences. Such tumors have been designated as replication errors (RER) tumors. However, as microsatellites are only rarely found within coding regions of the genome, instability of these sequences cannot directly contribute to carcinogenesis. Recently, we have shown RER colon cancers also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to DNA Replication

Share to Microsatellite Repeats

Share to Molecular Sequence Data

Share to Mutation

Share to RNA Splicing

Source

Identifiers

PMID: 8622858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability.PMID 8622858Read ↗

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.Semantic proximity Read ↗

Hypermutability and mismatch repair deficiency in RER+ tumor cells.Semantic proximity Read ↗

Genomic instability occurs in colorectal carcinomas but not in adenomasSemantic proximity Read ↗

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation.Semantic proximity Read ↗

Defective Mismatch Repair, Microsatellite Mutation Bias, and Variability in Clinical Cancer PhenotypesSemantic proximity Read ↗

Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype.Semantic proximity Read ↗

Microsatellite instability in inherited and sporadic neoplasms.Semantic proximity Read ↗

Frequent alterations in gene expression in colon tumor cells of the microsatellite mutator phenotype.Semantic proximity Read ↗

Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites.Semantic proximity Read ↗

BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.Semantic proximity Read ↗

A subgroup of microsatellite stable colorectal cancers has elevated mutation rates and different responses to alkylating and oxidising agents.Semantic proximity Read ↗

Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.