Frequency of replication errors in colorectal cancer and their association with family history.

doi:10.1136/gut.43.4.553

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Article

Frequency of replication errors in colorectal cancer and their association with family history.

Gut - 1 Oct 1998

Brown S R, Finan P J, Cawkwell L, Quirke P, Bishop D T

Abstract excerpt

BACKGROUND: Replication errors (RERs) characterise tumours of hereditary non-polyposis colorectal cancer (HNPCC). RER status may therefore improve identification of such families previously diagnosed by family history alone. AIMS: To assess RER and HNPCC frequency within a population of colorecta...

Topics

Adult
Aged
Aged, 80 and over
Base Pair Mismatch
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Replication
Female
Humans
Male
Middle Aged
Pedigree
Phenotype

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