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Article

Identification of a breast tumor with microsatellite instability in a potential carrier of the hereditary non-polyposis colon cancer trait.

Clinical genetics - 1 Jun 1995

Bergthorsson J T, Egilsson V, Gudmundsson J, Arason A, Ingvarsson S

Abstract excerpt

Allelic expansion at microsatellite loci in colorectal tumor DNA indicates a genomic instability caused by defects in DNA mismatch repair. This is observed in a high proportion of tumors from individuals affected by hereditary non-polyposis colorectal carcinoma, but to a lesser extent in sporadic colorectal tumors. In this study we screened 46 colorectal tumors for replication errors (RER). Tumors from six...

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Breast Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Replication
DNA, Neoplasm
DNA, Satellite
Female
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Pedigree

Phenotype

Source

Identifiers

PMID: 7554364
DOI: 10.1111/j.1399-0004.1995.tb03970.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7554364-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Identification of a breast tumor with microsatellite instability in a potential carrier of the hereditary non-polyposis colon cancer trait.PMID 7554364Read ↗

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