Article
Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours.
Human mutation - 1 Jan 1998
Homfray T F, Cottrell S E, Ilyas M, Rowan A, Talbot I C, Bodmer W F, Tomlinson I P
Abstract excerpt
The roles of the intrinsic mutation rate and genomic instability in tumorigenesis are currently controversial. In most colorectal tumours, it is generally supposed that the first mutations occur at the adenomatous polyposis coli (APC) locus; APC mutations are thought to provide cells with a selective advantage but have no known effect on the mutation rate. It has also been suggested that genomic instability is...
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