Article
Adenovirus 5 E1A induced differentiation of P19 embryonal carcinoma cells requires binding to p300.
Oncogene - 5 Jan 1995
Slack R S, Craig J, Costa S, McBurney M W
Abstract excerpt
We transfected P19 embryonal carcinoma (EC) cells with genes encoding the adenovirus 5 E1A products. Expression of either the 12S or 13S transcripts yielded P19 cells either incapable of proliferating or able to proliferate but having lost the characteristics of the EC cell parent. The proliferating clones of E1A expressing P19 cells were incapable of differentiating in response to retinoic acid or dimethyl...
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