Adenovirus 5 E1A induced differentiation of P19 embryonal carcinoma cells requires binding to p300.

Article

Adenovirus 5 E1A induced differentiation of P19 embryonal carcinoma cells requires binding to p300.

Oncogene - 5 Jan 1995

Slack R S, Craig J, Costa S, McBurney M W

Abstract excerpt

We transfected P19 embryonal carcinoma (EC) cells with genes encoding the adenovirus 5 E1A products. Expression of either the 12S or 13S transcripts yielded P19 cells either incapable of proliferating or able to proliferate but having lost the characteristics of the EC cell parent. The proliferat...

Topics

Adenovirus E1A Proteins
Carcinoma, Embryonal
Cell Differentiation
Endoderm
Mutation
Nuclear Proteins
Protein Binding
Sequence Deletion
Trans-Activators
Transcription Factors
Tumor Cells, Cultured

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