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Article

Requirement of the adenovirus E1A transformation domain 1 for inhibition of PC12 cell neuronal differentiation.

Cell regulation - 1 Jun 1991

Heasley L E, Benedict S, Gleavy J, Johnson G L

Abstract excerpt

Expression of the adenovirus early gene E1A inhibits the nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma cells. Expression of the 12S form of E1A, which lacks the transcription activation region, also inhibited PC12 cell differentiation in a manner similar to the wild-type gene. Three cellular proteins--the retinoblastoma susceptibility gene product referred to as 105(Rb)-, 107-, and...

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Identifiers

PMID: 1832020
DOI: 10.1091/mbc.2.6.479
PMCID: PMC361834

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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