Requirement of the adenovirus E1A transformation domain 1 for inhibition of PC12 cell neuronal differentiation.

doi:10.1091/mbc.2.6.479

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Article

Requirement of the adenovirus E1A transformation domain 1 for inhibition of PC12 cell neuronal differentiation.

Cell regulation - 1 Jun 1991

Heasley L E, Benedict S, Gleavy J, Johnson G L

Abstract excerpt

Expression of the adenovirus early gene E1A inhibits the nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma cells. Expression of the 12S form of E1A, which lacks the transcription activation region, also inhibited PC12 cell differentiation in a manner similar to the wild-t...

Topics

Adenovirus Early Proteins
Animals
Cell Differentiation
Gene Expression Regulation
Mutation
Nerve Growth Factors
Oncogene Proteins, Viral
Phenotype
RNA, Messenger
Transfection
Tumor Cells, Cultured

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