Article
Relationship between alkaline phosphatase levels, osteopontin expression, and mineralization in differentiating MC3T3-E1 osteoblasts.
Journal of cellular biochemistry - 1 Feb 1998
Beck G R, Sullivan E C, Moran E, Zerler B
Abstract excerpt
We are using viral oncogene probes to study the pathways by which osteoblast-specific gene expression is induced in ascorbic acid-treated MC3T3-E1 cells. The 12S product of the adenovirus E1A gene binds directly to key cellular regulators and, as a result, represses tissue specific gene expressio...
Topics
- 3T3 Cells
- Adenovirus E1A Proteins
- Alkaline Phosphatase
- Animals
- Biomarkers
- Bone and Bones
- Calcification, Physiologic
- Cell Differentiation
- Collagen
- Enzyme Induction
- Gene Expression Regulation, Enzymologic
- Genes, Viral
- Genetic Variation
- Mice
- Osteoblasts
- Osteocalcin
- Osteonectin
- Osteopontin
