The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function.

doi:10.1128/JVI.64.1.161-172.1990

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function.

Journal of virology - 1 Jan 1990

Herbst R S, Pelletier M, Boczko E M, Babiss L E

Abstract excerpt

Most of the eucaryotic enhancer elements so far described consist of multiple DNA binding sites for proteins that act either synergistically or antagonistically to modulate the rate of transcription. In this report, we show that the activity of the adenovirus E1A enhancer element is suppressed in...

Topics

Adenovirus Early Proteins
Adenoviruses, Human
Animals
Base Sequence
Cell Differentiation
Cell Line
Cell Nucleus
DNA-Binding Proteins
Enhancer Elements, Genetic
Gene Expression
Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Viral

HeLa Cells

Humans

Molecular Sequence Data

Mutation

Oncogene Proteins, Viral

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2136708
DOI: 10.1128/JVI.64.1.161-172.1990
PMCID: PMC249075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2136708-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function.PMID 2136708Read ↗

Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cellsSemantic proximity Read ↗

Differential activation of the E2F transcription factor by the adenovirus EIa and EIV products in F9 cells.Semantic proximity Read ↗

Adenovirus E1A Targets the DREF Nuclear Factor To Regulate Virus Gene Expression, DNA Replication, and GrowthSemantic proximity Read ↗

Epigenetic reprogramming by adenovirus e1a.Semantic proximity Read ↗

The adenovirus EII early promoter has multiple EIA-sensitive elements, two of which function cooperatively in basal and virus-induced transcription.Semantic proximity Read ↗

The role of CCAAT/enhancer-binding protein in the differential transcriptional regulation of a family of human liver alcohol dehydrogenase genes.Semantic proximity Read ↗

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein.Semantic proximity Read ↗

Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cellsSemantic proximity Read ↗

Adenovirus E1A-p105(Rb) protein interactions play a direct role in the initiation but not the maintenance of the rodent cell transformed phenotype.Semantic proximity Read ↗

A mutated polyoma virus enhancer which is active in undifferentiated embryonal carcinoma cells is not repressed by adenovirus-2 E1A products.Semantic proximity Read ↗

Liver-enriched HNF-3 alpha and ubiquitous factors interact with the human transferrin gene enhancer.Semantic proximity Read ↗

CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.