Article
Molecular analysis of the RhD genotype in fetuses at risk for RhD hemolytic disease.
Obstetrics and gynecology - 1 Feb 1995
Spence W C, Maddalena A, Demers D B, Bick D P
Abstract excerpt
The objective of this study was to evaluate the accuracy of a DNA-based testing methodology in determining the RhD genotypes of fetuses at risk for RhD hemolytic disease. We designed a multiplex polymerase chain reaction-based test based on recent RhD and RhCE sequence information. To improve the accuracy of the results, two different portions of the RhD gene were examined. Deoxyribonucleic acid was extracted...
Topics
- Erythroblastosis, Fetal
- Female
- Genotype
- Humans
- Infant, Newborn
- Polymerase Chain Reaction
- Pregnancy
- Prenatal Diagnosis
- Rh-Hr Blood-Group System
- Risk Factors
