Article
Reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD negative women.
Prenatal diagnosis - 1 Nov 2005
Clausen Frederik Banch, Krog Grethe Risum, Rieneck Klaus, Nielsen Leif Kofoed, Lundquist Rasmus, Finning Kirstin, Dickmeiss Ebbe, Hedegaard Morten, Dziegiel Morten Hanefeld
Abstract excerpt
OBJECTIVES: The objective of this study was to establish a reliable test for prenatal prediction of fetal RhD type using maternal plasma from RhD negative women. This test is needed for future prenatal Rh prophylaxis. METHODS: A novel real-time PCR-based assay targeting RHD exon 7 combined with a published assay for RHD exon 10 were used to determine the fetal RHD status in DNA extracted from plasma, sampled from...
Topics
- DNA
- DNA Probes
- Exons
- Female
- Fetal Diseases
- Genotype
- Gestational Age
- Humans
- Polymerase Chain Reaction
- Predictive Value of Tests
- Pregnancy
- Prenatal Diagnosis
- Reproducibility of Results