Article
Noninvasive prenatal RHD genotyping by real-time polymerase chain reaction using plasma from D-negative pregnant women.
American journal of obstetrics and gynecology - 1 Dec 2005
Zhou Lan, Thorson John A, Nugent Clark, Davenport Robertson D, Butch Suzanne H, Judd W John
Abstract excerpt
OBJECTIVE: Prenatal noninvasive determination of fetal Rh status is an important aid to the management of hemolytic disease of the fetus and newborn. We performed real-time polymerase chain reaction on fetal DNA derived from maternal plasma to determine fetal Rh status. STUDY DESIGN: Cell-free plasma DNA from 98 D-negative pregnant women was tested for the presence of exons 4, 5, and 10 of RHD. The presence of...
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