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Clinical Validation of a Prenatal Cell-Free DNA Screening Test for Fetal RHD in a Large U.S. Cohort.

Obstetrics and gynecology - 1 Feb 2025

Gilstrop Thompson Marisa, Xu Wenbo, Moore Bridget, Wang Tina, Sun Nicholas, Pewar Hemant, Avent Neil D, Vernaza Abelardo, Acosta Felipe, Saben Jessica L, Souter Vivienne, Parmar Sheetal, Sengupta Urmi, Altug Yucel, EmBree Joshua, Cantos Carlos, Kotwaliwale Chitra, Babiarz Joshua, Zimmermann Bernhard, Swenerton Ryan, Meltzer Jeffrey T

Abstract excerpt

OBJECTIVE: To present a large U.S. clinical validation of a next-generation sequencing-based, noninvasive prenatal cell-free DNA test for fetal RHD . METHODS: This clinical validation study assessed the performance of a commercially available, next-generation sequencing-based cell-free DNA test for fetal RHD status. Samples that passed quality metrics were included if the patient had a previously reported...

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PMID: 39591628
DOI: 10.1097/AOG.0000000000005794
PMCID: PMC11731044

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RHD

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