Article
Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma.
The New England journal of medicine - 10 Dec 1998
Lo Y M, Hjelm N M, Fidler C, Sargent I L, Murphy M F, Chamberlain P F, Poon P M, Redman C W, Wainscoat J S
Abstract excerpt
BACKGROUND: The ability to determine fetal RhD Status noninvasively is useful in the treatment of RhD-sensitized pregnant women whose partners are heterozygous for the RhD gene. The recent demonstration of fetal DNA in maternal plasma raises the possibility that fetal RhD genotyping may be possib...
Topics
- Blood Grouping and Crossmatching
- DNA
- Female
- Fetal Blood
- Genotype
- Humans
- Polymerase Chain Reaction
- Pregnancy
- Prenatal Diagnosis
- Rh Isoimmunization
- Rh-Hr Blood-Group System
- Sensitivity and Specificity