Article
Apolipoprotein E genotype and Lewy body disease.
Neurology - 1 Jan 1995
Lippa C F, Smith T W, Saunders A M, Crook R, Pulaski-Salo D, Davies P, Hardy J, Roses A D, Dickson D
Abstract excerpt
To determine whether apolipoprotein E (APOE) genotype affects neuropathology in Lewy body disease (LBD), we examined 18 cases of LBD that did not have concurrent Alzheimer's disease by the CERAD criteria. We obtained APOE genotypes, determined diffuse beta-amyloid plaque (A beta P) and Lewy body densities in multiple brain regions, and graded the intensity of CA2-3 ubiquitin-positive neurites, vacuolar change,...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoproteins E
- Brain
- Frontal Lobe
- Gene Frequency
- Genotype
- Hippocampus
- Humans