Article
The influence of Apolipoprotein E genotype on regional pathology in Alzheimer's disease.
BMC neurology - 11 May 2013
Sabbagh Marwan N, Malek-Ahmadi Michael, Dugger Brittany N, Lee Katarina, Sue Lucia I, Serrano Geidy, Walker Douglas G, Davis Kathryn, Jacobson Sandra A, Beach Thomas G
Abstract excerpt
BACKGROUND: Carriers of the ApoE ϵ4 allele are at a greater risk for developing Alzheimer's disease (AD) and those who do develop AD tend to have a much greater neuropathological disease burden. Although several studies have shown significant differences in AD pathology among ϵ4 carriers and non-carriers, few have characterized these differences in terms of brain region and neuropathological score frequency....
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