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Article

Apolipoprotein E-epsilon 2 and Alzheimer's disease: genotype influences pathologic phenotype.

Neurology - 1 Feb 1997

Lippa C F, Smith T W, Saunders A M, Hulette C, Pulaski-Salo D, Roses A D

Abstract excerpt

To determine whether apolipoprotein E epsilon 2 (APOE-epsilon 2) affects neuropathology in aging and Alzheimer's disease (AD), we compared beta-amyloid plaque (A beta P) and neurofibrillary tangle densities, neuropil thread formation, and amyloid angiopathy in five APOE-epsilon 2/3 AD patients, f...

Topics

Aged
Alleles
Alzheimer Disease
Amyloid beta-Peptides
Apolipoprotein E2
Apolipoprotein E3
Apolipoproteins E
Brain
Female
Genotype
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurofibrillary Tangles

Phenotype

Source

Identifiers

PMID: 9040748
DOI: 10.1212/wnl.48.2.515

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9040748-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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