Article
Regulatory role of the G alpha 1 subunit in controlling cellular morphogenesis in Dictyostelium.
Development (Cambridge, England) - 1 Dec 1994
Dharmawardhane S, Cubitt A B, Clark A M, Firtel R A
Abstract excerpt
To determine the function of the Dictyostelium G alpha 1 subunit during aggregation and multicellular development, we analyzed the phenotypes of g alpha 1 null cells and strains overexpressing either wild-type G alpha 1 or two putative constitutively active mutations of G alpha 1. Strains overexpressing the wild-type or mutant G alpha 1 proteins showed very abnormal culmination with an aberrant stalk...
Topics
- Animals
- Blotting, Western
- Cell Differentiation
- Cyclic AMP
- Cyclic GMP
- Dictyostelium
- GTP-Binding Proteins
- Gene Expression
- Genes, Protozoan
- Morphogenesis
- Phenotype