Article
Temperature-sensitive Gbeta mutants discriminate between G protein-dependent and -independent signaling mediated by serpentine receptors.
The EMBO journal - 1 Sept 1998
Jin T, Soede R D, Liu J, Kimmel A R, Devreotes P N, Schaap P
Abstract excerpt
Deletion of the single gene for the Dictyostelium G protein beta-subunit blocks development at an early stage. We have now isolated temperature-sensitive alleles of Gbeta to investigate its role in later development. We show that Gbeta is directly required for adenylyl cyclase A activation and fo...
Topics
- Adenylyl Cyclases
- Alleles
- Amino Acid Sequence
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Adhesion
- Cell Differentiation
- Cyclic AMP
- Dictyostelium
- Enzyme Activation
- GTP-Binding Proteins
- Gene Expression Regulation
- Glycogen Synthase Kinase 3
- Hot Temperature