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Article

Temperature-sensitive Gbeta mutants discriminate between G protein-dependent and -independent signaling mediated by serpentine receptors.

The EMBO journal - 1 Sept 1998

Jin T, Soede R D, Liu J, Kimmel A R, Devreotes P N, Schaap P

Abstract excerpt

Deletion of the single gene for the Dictyostelium G protein beta-subunit blocks development at an early stage. We have now isolated temperature-sensitive alleles of Gbeta to investigate its role in later development. We show that Gbeta is directly required for adenylyl cyclase A activation and for morphogenetic signaling during the entire developmental program. Gbeta was also essential for induction of...

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Identifiers

PMID: 9724643
DOI: 10.1093/emboj/17.17.5076
PMCID: PMC1170835

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