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Article

The G alpha subunit Gα8 inhibits proliferation, promotes adhesion and regulates cell differentiation.

Developmental biology - 1 Aug 2013

Wu Yuantai, Janetopoulos Chris

Abstract excerpt

Heterotrimeric G protein-mediated signal transduction plays a pivotal role in both vegetative and developmental stages in the eukaryote Dictyostelium discoideum. Here we describe novel functions of the G protein alpha subunit Gα8 during vegetative and development stages. Gα8 is expressed at low levels during vegetative growth. Loss of Gα8 promotes cell proliferation, whereas excess Gα8 expression dramatically...

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Identifiers

PMID: 23665473
DOI: 10.1016/j.ydbio.2013.05.001
PMCID: PMC3754877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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