Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.

Oncogene - 7 Jan 2016

Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton P E, Hay R T, Dobner T, Schreiner S

Abstract excerpt

Although modulation of the cellular tumor-suppressor p53 is considered to have the major role in E1A/E1B-55K-mediated tumorigenesis, other promyelocytic leukemia nuclear body (PML-NB)/PML oncogenic domain (POD)-associated factors including SUMO, Mre11, Daxx, as well as the integrity of these nuclear bodies contribute to the transformation process. However, the biochemical consequences and oncogenic alterations of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Cell Transformation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Leukemia, Promyelocytic, Acute

Share to Promyelocytic Leukemia Protein

Share to Protein Isoforms

Share to Tumor Suppressor Protein p53

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 25772236
DOI: 10.1038/onc.2015.63

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.PMID 25772236Read ↗

Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies.Semantic proximity Read ↗

E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene ExpressionSemantic proximity Read ↗

Human Adenovirus (HAdV) mediated inhibition of the tumor suppressor p53 is controlled by SUMOylation of the viral E2A/DBP proteinSemantic proximity Read ↗

The human adenovirus E1B-55K oncoprotein coordinates cell transformation through regulation of DNA-bound host transcription factorsSemantic proximity Read ↗

Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.Semantic proximity Read ↗

Adenovirus E4orf3 Targets Transcriptional Intermediary Factor 1γ for Proteasome-Dependent Degradation during InfectionSemantic proximity Read ↗

Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.Semantic proximity Read ↗

Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A.Semantic proximity Read ↗

Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complex.Semantic proximity Read ↗

Cross Talk between PML and p53 during Poliovirus Infection: Implications for Antiviral DefenseSemantic proximity Read ↗

The E3 ubiquitin ligase activity associated with the adenoviral E1B-55K-E4orf6 complex does not require CRM1-dependent export.Semantic proximity Read ↗

Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.