Article
Selectable retrovirus vectors encoding Friend virus gp55 or erythropoietin induce polycythemia with different phenotypic expression and disease progression.
Journal of virology - 1 Nov 1994
Ahlers N, Hunt N, Just U, Laker C, Ostertag W, Nowock J
Abstract excerpt
The Friend spleen focus-forming virus induces a massive expansion of erythroid progenitor cells resulting in polycythemia and splenomegaly. The pathogenic agent is the membrane glycoprotein gp55, encoded by the env gene. Recent evidence indicates that gp55 binds to and activates the erythropoieti...
Topics
- Animals
- Base Sequence
- Erythroid Precursor Cells
- Erythropoietin
- Female
- Genetic Vectors
- Mice
- Mice, Inbred DBA
- Molecular Sequence Data
- Phenotype
- Polycythemia
- Spleen Focus-Forming Viruses
- Viral Envelope Proteins