Article
A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.
Journal of virology - 1 Jun 1994
Hoatlin M E, Ferro F E, Kozak S L, Kabat D
Abstract excerpt
The Pvu delta mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, Pvu delta causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain P...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Primers
- DNA, Viral
- Friend murine leukemia virus
- Gene Products, env
- Leukemia, Erythroblastic, Acute
- Mice
- Molecular Sequence Data
- Mutation
- Receptors, Erythropoietin
- Retroviridae Infections
- Sequence Homology, Amino Acid
- Tumor Cells, Cultured
- Tumor Virus Infections
- Virulence