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Article

A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.

Journal of virology - 1 Jun 1994

Hoatlin M E, Ferro F E, Kozak S L, Kabat D

Abstract excerpt

The Pvu delta mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, Pvu delta causes erythroblastosis and the development of erythroleukemia. We isolated two leukemic cell lines that contain Pvu delta; both synthesize hemoglobin in response to dimethyl sulfoxide. The Pvu delta env gene contains a 204-base...

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Identifiers

PMID: 8189542
DOI: 10.1128/JVI.68.6.4053-4056.1994
PMCID: PMC236916

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Related research

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Research trail→

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A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.PMID 8189542Read ↗

Impaired activation and binding of the erythropoietin receptor by a mutant gp55 of Friend spleen focus-forming virus, which has a cytoplasmic domain.Semantic proximity Read ↗

Selectable retrovirus vectors encoding Friend virus gp55 or erythropoietin induce polycythemia with different phenotypic expression and disease progression.Semantic proximity Read ↗

Fusion of the erythropoietin receptor and the Friend spleen focus-forming virus gp55 glycoprotein transforms a factor-dependent hematopoietic cell line.Semantic proximity Read ↗

A Friend virus mutant that overcomes Fv-2rr host resistance encodes a small glycoprotein that dimerizes, is processed to cell surfaces, and specifically activates erythropoietin receptors.Semantic proximity Read ↗

Mutations in the env gene of friend spleen focus-forming virus overcome Fv-2r-mediated resistance to Friend virus-induced erythroleukemia.Semantic proximity Read ↗

Pathogenesis of Friend leukemia virus.Semantic proximity Read ↗

Deletions in one domain of the Friend virus-encoded membrane glycoprotein overcome host range restrictions for erythroleukemia.Semantic proximity Read ↗

Pathogenicity of a mutant friend spleen focus-forming virus encoding an Env-like membrane glycoprotein (gp55) with substitution by a xenotropic murine leukemia virus Env gp70 sequence.Semantic proximity Read ↗

Mutation in murine erythropoietin receptor induces erythropoietin-independent erythroid proliferation in vitro, polycythemia in vivo.Semantic proximity Read ↗

Cell surface site for mitogenic interaction of erythropoietin receptors with the membrane glycoprotein encoded by Friend erythroleukemia virus.Semantic proximity Read ↗

Mutation of the Lyn tyrosine kinase delays the progression of Friend virus induced erythroleukemia without affecting susceptibility.Semantic proximity Read ↗

Loss of p53 tumor suppressor function is required for in vivo progression of Friend erythroleukemia.Semantic proximity Read ↗

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