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Article

Mutations in the env gene of friend spleen focus-forming virus overcome Fv-2r-mediated resistance to Friend virus-induced erythroleukemia.

Journal of virology - 1 Jun 1992

Majumdar M K, Cho C L, Fox M T, Eckner K L, Kozak S, Kabat D, Geib R W

Abstract excerpt

Although Fv-2r homozygous mice are resistant to leukemias induced either by an erythropoietin-encoding virus or by wild-type Friend virus (FV) (M. E. Hoatlin, S. L. Kozak, F. Lilly, A. Chakraborti, C. A. Kozak, and D. Kabat, Proc. Natl. Acad. Sci. USA 87:9985-9989, 1990), they are susceptible to some variants of FV (R. A. Steeves, E. A. Mirand, A. Bulba, and P. J. Trudel, Int. J. Cancer 5:349-356, 1970; R. W....

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Transformation, Neoplastic
Cloning, Molecular
Friend murine leukemia virus
Gene Amplification
Genes, env
Host-Parasite Interactions
Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Erythroblastic, Acute

Leukemia, Experimental

Mice

Mice, Inbred Strains

Molecular Sequence Data

Mutation

Sequence Homology, Nucleic Acid

Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 1583724
DOI: 10.1128/JVI.66.6.3652-3660.1992
PMCID: PMC241148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1583724-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutations in the env gene of friend spleen focus-forming virus overcome Fv-2r-mediated resistance to Friend virus-induced erythroleukemia.PMID 1583724Read ↗

A Friend virus mutant that overcomes Fv-2rr host resistance encodes a small glycoprotein that dimerizes, is processed to cell surfaces, and specifically activates erythropoietin receptors.Semantic proximity Read ↗

A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.Semantic proximity Read ↗

Pathogenicity of a mutant friend spleen focus-forming virus encoding an Env-like membrane glycoprotein (gp55) with substitution by a xenotropic murine leukemia virus Env gp70 sequence.Semantic proximity Read ↗

Impaired activation and binding of the erythropoietin receptor by a mutant gp55 of Friend spleen focus-forming virus, which has a cytoplasmic domain.Semantic proximity Read ↗

A deletion in the Friend spleen focus-forming virus env gene is necessary for its product (gp55) to be leukemogenic.Semantic proximity Read ↗

Fusion of the erythropoietin receptor and the Friend spleen focus-forming virus gp55 glycoprotein transforms a factor-dependent hematopoietic cell line.Semantic proximity Read ↗

Pathogenesis of Friend leukemia virus.Semantic proximity Read ↗

Deletions in one domain of the Friend virus-encoded membrane glycoprotein overcome host range restrictions for erythroleukemia.Semantic proximity Read ↗

The envelope glycoprotein of friend spleen focus-forming virus covalently interacts with and constitutively activates a truncated form of the receptor tyrosine kinase Stk.Semantic proximity Read ↗

Role of N-terminal sequences of the tyrosine kinase sf-Stk in transformation of rodent fibroblasts by variants of Friend spleen focus-forming virus.Semantic proximity Read ↗

Selectable retrovirus vectors encoding Friend virus gp55 or erythropoietin induce polycythemia with different phenotypic expression and disease progression.Semantic proximity Read ↗

A carboxy-terminal mutant spleen focus-forming virus (SFFV) envelope glycoprotein is transport-competent, but non-leukemogenic.Semantic proximity Read ↗

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