Article
Impaired activation and binding of the erythropoietin receptor by a mutant gp55 of Friend spleen focus-forming virus, which has a cytoplasmic domain.
Virology - 5 Jul 1998
Yugawa T, Amanuma H
Abstract excerpt
A murine erythroleukemogenic retrovirus, Friend spleen focus-forming virus, encodes an envelope protein-like membrane glycoprotein (gp55) in its defective env gene which is responsible for activation of the erythropoietin receptor (EpoR) and the abnormally rapid proliferation of erythroid precursor cells. The S34 mutant gp55, which possesses an additional cytoplasmic domain, is nonpathogenic and its processing to...
Topics
- Animals
- Cell Line
- Dimerization
- Disulfides
- Erythropoietin
- Humans
- Membrane Glycoproteins
- Mice
- Mitogens
- Mutation
- Receptors, Erythropoietin
- Spleen Focus-Forming Viruses