Article
Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance.
Science (New York, N.Y.) - 21 Nov 2014
Rasmussen Angela L, Okumura Atsushi, Ferris Martin T, Green Richard, Feldmann Friederike, Kelly Sara M, Scott Dana P, Safronetz David, Haddock Elaine, LaCasse Rachel, Thomas Matthew J, Sova Pavel, Carter Victoria S, Weiss Jeffrey M, Miller Darla R, Shaw Ginger D, Korth Marcus J, Heise Mark T, Baric Ralph S, de Villena Fernando Pardo-Manuel, Feldmann Heinz, Katze Michael G
Abstract excerpt
Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated intravascular coagulation nor death from shock, thus restricting pathogenesis studies to nonhuman primates. Here we show that mice from the Collaborative Cross panel of recombinant inbred mice exhibit distinct disease phenotypes after mouse-adapted...
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