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Article

The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins.

The Journal of biological chemistry - 31 Oct 2003

Constantinescu Stefan N, Keren Tzvia, Russ William P, Ubarretxena-Belandia Iban, Malka Yaniv, Kubatzky Katharina F, Engelman Donald M, Lodish Harvey F, Henis Yoav I

Abstract excerpt

Erythropoietin receptor (EpoR) activation is crucial for mature red blood cell production. The murine EpoR can also be activated by the envelope protein of the polycythemic (P) spleen focus forming virus (SFFV), gp55-P. Due to differences in the TM sequence, gp55 of the anemic (A) strain SFFV, gp55-A, cannot efficiently activate the EpoR. Using antibody-mediated immunofluorescence co-patching, we show that the...

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PMID: 12930840
DOI: 10.1074/jbc.M302974200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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