Article
Knockout mutants of Actinobacillus pleuropneumoniae serotype 1 that are devoid of RTX toxins do not activate or kill porcine neutrophils.
Infection and immunity - 1 Jan 1995
Jansen R, Briaire J, Smith H E, Dom P, Haesebrouck F, Kamp E M, Gielkens A L, Smits M A
Abstract excerpt
The Actinobacillus pleuropneumoniae RTX-toxins ApxI, ApxII, and ApxIII are important virulence factors of this swine pathogen. It is hypothesized that the Apx toxins are deleterious to defense cells of the host, enabling the bacterium to infect the host. To confirm this, we studied the effect on porcine polymorphonuclear neutrophils of mutant strains of A. pleuropneumoniae that were devoid of Apx toxins. For this...
Topics
- Actinobacillus pleuropneumoniae
- Animals
- Bacterial Proteins
- Bacterial Toxins
- Base Sequence
- Cell Death
- Drug Resistance, Microbial
- Electroporation
- Genotype
- Hemolysin Proteins