Article
The RTX haemolysins ApxI and ApxII are major virulence factors of the swine pathogen Actinobacillus pleuropneumoniae: evidence from mutational analysis.
Molecular microbiology - 1 Oct 1994
Tascón R I, Vázquez-Boland J A, Gutiérrez-Martín C B, Rodríguez-Barbosa I, Rodríguez-Ferri E F
Abstract excerpt
The involvement of the RTX haemolysins (ApxI and ApxII) of the swine pathogen Actinobacillus pleuropneumoniae in virulence was investigated using haemolysin-deficient mutants constructed by a mini-Tn10 mutagenesis procedure. Two types of haemolysin mutant with single insertions of the transposon were obtained from a serotype 1 strain producing both ApxI and ApxII. One presented a complete loss of haemolytic...
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