Article
Potential use an Actinobacillus pleuropneumoniae double mutant strain DeltaapxIICDeltaapxIVA as live vaccine that allows serological differentiation between vaccinated and infected animals.
Vaccine - 1 Nov 2007
Liu Jinlin, Chen Xia, Lin Liwen, Tan Chen, Chen Yan, Guo Yi, Jin Meilin, Guo Aizhen, Bei Weicheng, Chen Huanchun
Abstract excerpt
Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, a highly contagious and often fatal disease. We have previously reported the construction and characterization of a single gene apxIIC deletion mutant HB04C(-) based on A. pleuropneumoniae serovar 7 which produces ApxII toxin and ApxIV. A precisely defined DeltaapxIICDeltaapxIVA double-deletion mutant of A. pleuropneumoniae was...
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