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Article

Construction and immunogencity of a DeltaapxIC/DeltaapxIIC double mutant of Actinobacillus pleuropneumoniae serovar 1.

FEMS microbiology letters - 1 Sept 2007

Lin Liwen, Bei Weicheng, Sha Yonggang, Liu Jinlin, Guo Yi, Liu Weihong, Tu Shuxin, He Qigai, Chen Huanchun

Abstract excerpt

The apxIC and apxIIC genes of the Actinobacillus pleuropneumoniae serovar 1 strain SLW01, encoding the ApxI- and ApxII-activating proteins, respectively, were deleted successively by a method involving sucrose counterselection. The resulting strain, SLW03, contained no foreign DNA and could secrete unactivated ApxIA and ApxIIA RTX toxins with complete antigenicity. Strain SLW03 was attenuated at least 1000-fold...

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PMID: 17608699
DOI: 10.1111/j.1574-6968.2007.00813.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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