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Article

[Reversal of malignant phenotype of human hepatoma cells by antisense c-ets-2, c-myc and N-ras].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Jul 1994

Huang X M, Wei S G, Wang L F

Abstract excerpt

A recombinant retroviral vector was constructed which expressed antisense RNA of c-ets-2, c-myc and N-ras. The pseudotype virus was packaged and rescued by transfection in PA317 cells and used to infect human hepatoma cell line SMMC-7721. After selection with G418, resistant colonies were obtained. Stable integration of retrovirus in infectants was shown by Southern hybridization of genomic DNA and the presence...

Topics

Animals
Carcinoma, Hepatocellular
Genes, myc
Genes, ras
Humans
Liver Neoplasms
Mice
Mice, Nude
Phenotype
Proto-Oncogene Proteins
RNA, Antisense
Retroviridae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 7805549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7805549-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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