Article
Antisense downregulation of N-myc1 in woodchuck hepatoma cells reverses the malignant phenotype.
Journal of virology - 1 Mar 1998
Wang H P, Zhang L, Dandri M, Rogler C E
Abstract excerpt
Cell line WH44KA is a highly malignant woodchuck hepatoma cell line. WH44KA cells contain a single woodchuck hepatitis virus (WHV) DNA integration in the 3' untranslated region of exon 3 of the woodchuck N-myc1 gene. The highly rearranged WHV DNA contains WHV enhancers which activate the N-myc pr...
Topics
- Animals
- Base Sequence
- Carcinoma, Hepatocellular
- Cell Line
- DNA, Viral
- Gene Expression
- Gene Expression Regulation, Viral
- Genes, myc
- Genetic Vectors
- Hepatitis B Virus, Woodchuck
- Marmota
- Mice
- Mice, Nude
- Molecular Sequence Data
- Nucleic Acid Conformation
- Phenotype
- RNA, Antisense
- RNA, Viral