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Article

Inhibition of fibroblast growth factor 2 expression by antisense RNA induced a loss of the transformed phenotype in a human hepatoma cell line.

Cancer research - 1 Nov 1995

Maret A, Galy B, Arnaud E, Bayard F, Prats H

Abstract excerpt

Fibroblast growth factor 2 (FGF-2 or basic FGF) is associated with the cell-transformed phenotype. To clarify the function of FGF-2 in the malignancy of tumor cells, we designed experiments to express antisense RNA in a hepatoma cell line. Using FGF-2 mRNA, alternative initiations of translation at one AUG and three CUG start codons led to the synthesis of four isoforms. SK-Hep1 cells, which naturally produce the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 7585554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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