Article
Inhibition of fibroblast growth factor 2 expression by antisense RNA induced a loss of the transformed phenotype in a human hepatoma cell line.
Cancer research - 1 Nov 1995
Maret A, Galy B, Arnaud E, Bayard F, Prats H
Abstract excerpt
Fibroblast growth factor 2 (FGF-2 or basic FGF) is associated with the cell-transformed phenotype. To clarify the function of FGF-2 in the malignancy of tumor cells, we designed experiments to express antisense RNA in a hepatoma cell line. Using FGF-2 mRNA, alternative initiations of translation...
Topics
- Animals
- Carcinoma, Hepatocellular
- Cell Adhesion
- Cell Division
- Cell Transformation, Neoplastic
- Fibroblast Growth Factor 2
- Humans
- Liver Neoplasms
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Phenotype
- RNA, Antisense
- RNA, Messenger
- Tumor Cells, Cultured