Article
[Suppression of metastatic phenotype of cloned mouse lung adenocarcinoma cells by transfer of human genomic DNA].
Zhonghua yi xue za zhi - 1 Nov 1997
Lu Y, Ge X, Fu S
Abstract excerpt
OBJECTIVE: To isolate and identify human sequences with metastatic suppression ability. METHODS: Genomic DNA fragments isolated from normal human lung tissue were transfected into cloned highly metastatic mouse lung adenocarcinoma cells together with PSV2neo as selectable marker. RESULTS: 25 transfectants were cloned in medium containing G418 and Ouabain. Eight morphologically flat revertants exhibited a more...
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