[Suppression of metastatic phenotype of cloned mouse lung adenocarcinoma cells by transfer of human genomic DNA].

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Article

[Suppression of metastatic phenotype of cloned mouse lung adenocarcinoma cells by transfer of human genomic DNA].

Zhonghua yi xue za zhi - 1 Nov 1997

Lu Y, Ge X, Fu S

Abstract excerpt

OBJECTIVE: To isolate and identify human sequences with metastatic suppression ability. METHODS: Genomic DNA fragments isolated from normal human lung tissue were transfected into cloned highly metastatic mouse lung adenocarcinoma cells together with PSV2neo as selectable marker. RESULTS: 25 transfectants were cloned in medium containing G418 and Ouabain. Eight morphologically flat revertants exhibited a more...

Topics

Adenocarcinoma
Animals
DNA Transposable Elements
Genes, Tumor Suppressor
Genome, Human
Humans
Lung Neoplasms
Mice
Mice, Inbred BALB C
Mice, Nude
Phenotype
Transfection
Tumor Cells, Cultured

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PMID: 9772476

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