Article
[Reversion of malignant phenotypes of human lung squamous carcinoma cells by ornithine decarboxylase antisense RNA].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Mar 1996
Guan J, Fan M, Cao S
Abstract excerpt
Abnormally elevated activity of ornithine decarboxylase (ODC), with subsequent polyamine accumulation are intimately associated with the genesis, development and metastasis of cancer. Therefore, ODC antisense RNA was used to transfect human lung squmous carcinoma cell line LTEP-78. Compared with the parental cells, growth of the antisense transfected LTEP-78 cells arrested in G0/G1 phase and colony formation in...
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