[Reversion of malignant phenotypes of human lung squamous carcinoma cells by ornithine decarboxylase antisense RNA].

Article

[Reversion of malignant phenotypes of human lung squamous carcinoma cells by ornithine decarboxylase antisense RNA].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Mar 1996

Guan J, Fan M, Cao S

Abstract excerpt

Abnormally elevated activity of ornithine decarboxylase (ODC), with subsequent polyamine accumulation are intimately associated with the genesis, development and metastasis of cancer. Therefore, ODC antisense RNA was used to transfect human lung squmous carcinoma cell line LTEP-78. Compared with...

Topics

Animals
Carcinoma, Squamous Cell
Cell Cycle
Humans
Lung Neoplasms
Male
Mice
Mice, Nude
Ornithine Decarboxylase
Phenotype
RNA, Antisense
RNA, Messenger
Transfection
Tumor Cells, Cultured

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