Article
Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions.
Cancer research - 1 Jan 1995
Sozzi G, Miozzo M, Pastorino U, Pilotti S, Donghi R, Giarola M, De Gregorio L, Manenti G, Radice P, Minoletti F
Abstract excerpt
Patients with a primary cancer in the lung or in the upper aerodigestive tract have an increased risk of developing synchronous or metachronous second primary lung tumors. This phenomenon has been related to the chronic exposure of the bronchial tree to carcinogens through a so-called "field cancerization" process. This study was designed to investigate at the somatic level the genetic basis of the field...
Topics
- Adenocarcinoma
- Base Sequence
- Carcinoma, Squamous Cell
- Chromosome Deletion
- Chromosomes, Human, Pair 3
- Genes, p53
- Genes, ras
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutation