Article
Cell migration leads to spatially distinct but clonally related airway cancer precursors.
Thorax - 1 Jun 2014
Pipinikas Christodoulos P, Kiropoulos Theodoros S, Teixeira Vitor H, Brown James M, Varanou Aikaterini, Falzon Mary, Capitanio Arrigo, Bottoms Steven E, Carroll Bernadette, Navani Neal, McCaughan Frank, George Jeremy P, Giangreco Adam, Wright Nicholas A, McDonald Stuart A C, Graham Trevor A, Janes Sam M
Abstract excerpt
BACKGROUND: Squamous cell carcinoma of the lung is a common cancer with 95% mortality at 5 years. These cancers arise from preinvasive lesions, which have a natural history of development progressing through increasing severity of dysplasia to carcinoma in situ (CIS), and in some cases, ending in transformation to invasive carcinoma. Synchronous preinvasive lesions identified at autopsy have been previously shown...
Topics
- Adult
- Carcinoma in Situ
- Carcinoma, Squamous Cell
- Cell Movement
- Genes, p53
- Humans
- Loss of Heterozygosity
- Lung Neoplasms
- Male
- Middle Aged