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Synchronous driver gene alterations (EGFR L858R, T790M, and ROS1) rearrangements in a patient with early-stage lung adenocarcinoma.

Cancer genetics - 1 Nov 2022

Masago Katsuhiro, Kuroda Hiroaki, Takahashi Yusuke, Oya Yuko, Sasaki Eiichi, Sakakura Noriaki, Matsushita Hirokazu

Abstract excerpt

Concurrent EGFR mutation and ROS1 rearrangement is a rare event in early-stage non-small-cell lung cancer. In addition, a co-occurring de novo EGFR T790M mutation in such a case is extremely rare. We encountered a 72-year-old woman who developed 3 early-stage lung lesions synchronously, one each harboring EGFR L858R, ROS1 rearrangement, and EGFR L858R and de novo T790M. These three nodules were pathologically...

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Identifiers

PMID: 36332423
DOI: 10.1016/j.cancergen.2022.09.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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