Article
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors.
Nature cancer - 1 Nov 2024
Burr Risa, Leshchiner Ignaty, Costantino Christina L, Blohmer Martin, Sundaresan Tilak, Cha Justin, Seeger Karsen, Guay Sara, Danysh Brian P, Gore Ira, Jacobs Raquel A, Slowik Kara, Utro Filippo, Rhrissorrakrai Kahn, Levovitz Chaya, Barth Jaimie L, Dubash Taronish, Chirn Brian, Parida Laxmi, Sequist Lecia V, Lennerz Jochen K, Mino-Kenudson Mari, Maheswaran Shyamala, Naxerova Kamila, Getz Gad, Haber Daniel A
Abstract excerpt
Although the development of multiple primary tumors in smokers with lung cancer can be attributed to carcinogen-induced field cancerization, the occurrence of multiple tumors at presentation in individuals with EGFR-mutant lung cancer who lack known environmental exposures remains unexplained. In the present study, we identified ten patients with early stage, resectable, non-small cell lung cancer who presented...
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