Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular evidence of field cancerization in a patient with 7 tumors of the aerodigestive tract.

Human pathology - 1 Feb 2000

van Rees B P, Cleton-Jansen A M, Cense H A, Polak M M, Clement M J, Drillenburg P, van Lanschot J J, Offerhaus G J

Abstract excerpt

Exposure of the mucosa of the upper aerodigestive tract to carcinogens can induce genetic changes resulting in various independent clones of neoplastic growth, a concept defined as "field cancerization." The risk of developing multiple tumors in this compartment of the body is well established. We studied 6 distinct tumors of the upper aerodigestive tract of a single patient for loss of heterozygosity (LOH),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Digestive System Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fatal Outcome

Share to Genes, p53

Share to Genes, ras

Share to Loss of Heterozygosity

Share to Microsatellite Repeats

Share to Neoplasms, Multiple Primary

Source

Identifiers

PMID: 10685648
DOI: 10.1016/s0046-8177(00)80234-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular evidence of field cancerization in a patient with 7 tumors of the aerodigestive tract.PMID 10685648Read ↗

Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract.Semantic proximity Read ↗

Perspectives on the molecular epidemiology of aerodigestive tract cancers.Semantic proximity Read ↗

A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications.Semantic proximity Read ↗

Field cancerization in the GI tract.Semantic proximity Read ↗

Clinical implications and utility of field cancerizationSemantic proximity Read ↗

Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions.Semantic proximity Read ↗

Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis.Semantic proximity Read ↗

Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors.Semantic proximity Read ↗

Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications.Semantic proximity Read ↗

Revisit of Field Cancerization in Squamous Cell Carcinoma of Upper Aerodigestive Tract: Better Risk Assessment with Epigenetic MarkersSemantic proximity Read ↗

Genetic and environmental interactions as risks for aerodigestive cancers.Semantic proximity Read ↗

Identification of clonal mutations in morphologically normal mucosa of the aerodigestive tract.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.