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Article

Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis.

15 Oct 1997

Abstract excerpt

Individuals with one aerodigestive tract malignancy have a high incidence of second primary aerodigestive tumors. The mechanism for this field effect has not been determined. We studied an individual with widespread dysplastic changes in the respiratory epithelium but no overt carcinoma. The entire tracheobronchial tree obtained at autopsy was embedded in paraffin, and bronchial epithelial cells were isolated by...

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Identifiers

PMID: 9329980
DOI: 10.1172/jci119748

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Source receipt: pubmed, retrieved 7 Sept 2026.

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