Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract.

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Article

Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract.

Cancer research - 1 Apr 1993

Chung K Y, Mukhopadhyay T, Kim J, Casson A, Ro J Y, Goepfert H, Hong W K, Roth J A

Abstract excerpt

Patients with primary head and neck malignancies have a 3-7% yearly incidence of second primary cancers. It is thought that these second primary cancers arise independently following exposure to a common carcinogen by a process that has been called field cancerization. Since mutations in the p53...

Topics

Adult
Aged
Amino Acid Sequence
Carcinoma, Squamous Cell
DNA Mutational Analysis
Esophageal Neoplasms
Exons
Female
Genes, p53
Head and Neck Neoplasms
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Neoplasms, Multiple Primary

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 8453641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8453641-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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