Article
Mutations of the P53 tumor suppressor gene as clonal marker for multiple primary lung cancers.
The Journal of thoracic and cardiovascular surgery - 1 Sept 1997
Mitsudomi T, Yatabe Y, Koshikawa T, Hatooka S, Shinoda M, Suyama M, Sugiura T, Ogawa M, Takahashi T
Abstract excerpt
OBJECTIVES: Second primary lung cancers are prevalent after treatment for initial lung cancer, and the lung is also one of the most frequent sites for recurrence after removal of early-stage lung cancer. The objective of the present study is to clarify the clonal origin of the second tumor with the p53 gene mutation used as a clonal marker. METHODS: Of 794 consecutive patients who underwent pulmonary resection...
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