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Article

Genetic evolution of epidermal growth factor receptor in adenocarcinoma with a bronchioloalveolar carcinoma component.

Clinical lung cancer - 1 May 2010

Zhong Wen-Zhao, Wu Yi-Long, Yang Xue-Ning, Guo Ai-Lin, Su Jian, Zhang Xu-Chao, Luo Dong-Lan, Wang Zhen, Chen Hua-Jun, Zhou Qing, Xu Chong-Rui, Qiao Gui-Bin, Liao Ri-Qiang, Yang Jin-Ji, Mok Tony S

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) mutations may accumulate during the multistage progression of bronchioloalveolar carcinoma (BAC), leading to heterogeneity within the tumor. This study sought to determine whether metachronous adenocarcinomas with a BAC component emerging in the lung field arise from a single or multiple clones in the same individual. MATERIALS AND METHODS: Samples of...

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Identifiers

PMID: 20439191
DOI: 10.3816/CLC.2010.n.020

Genes

EGFR

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