Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of 14-3-3 proteins with the insulin-like growth factor I receptor (IGFIR): evidence for a role of 14-3-3 proteins in IGFIR signaling.

Biochemical and biophysical research communications - 26 Dec 2003

Spence Susan L, Dey Bhakta R, Terry Cheryl, Albert Paul, Nissley Peter, Furlanetto Richard W

Abstract excerpt

We have extended our previous yeast two-hybrid findings to show that 14-3-3beta also interacts with the insulin-like growth factor I receptor (IGFIR) in mammalian cells overexpressing both proteins and that the interaction involves serine 1283 and is dependent on receptor activation. Treatment of cells with the phorbol ester PMA stimulates the interaction of 14-3-3beta with the IGFIR in the absence of receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Carcinogenicity Tests

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to COS Cells

Share to NIH 3T3 Cells

Share to Receptor, IGF Type 1

Share to Tetradecanoylphorbol Acetate

Share to Tyrosine 3-Monooxygenase

Source

Identifiers

PMID: 14651979
DOI: 10.1016/j.bbrc.2003.11.043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of 14-3-3 proteins with the insulin-like growth factor I receptor (IGFIR): evidence for a role of 14-3-3 proteins in IGFIR signaling.PMID 14651979Read ↗

14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor.Semantic proximity Read ↗

Unraveling Insulin-Like Growth Factor Binding Protein-3 Actions in Human DiseaseSemantic proximity Read ↗

Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid system.Semantic proximity Read ↗

Role of N- and C-terminal residues of insulin-like growth factor (IGF)-binding protein-3 in regulating IGF complex formation and receptor activation.Semantic proximity Read ↗

Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain.Semantic proximity Read ↗

Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit.Semantic proximity Read ↗

Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins.Semantic proximity Read ↗

Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Influences Sensitivity to Anti-IGF System Agents Through the Translational Regulation of IGF1RSemantic proximity Read ↗

Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor.Semantic proximity Read ↗

Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor.Semantic proximity Read ↗

Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesisSemantic proximity Read ↗

Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.