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Article

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

Molecular and cellular biology - 1 Feb 1990

Kaleko M, Rutter W J, Miller A D

Abstract excerpt

The human insulinlike growth factor I receptor was overexpressed in NIH 3T3 cells as well as human and rat primary fibroblast strains. The NIH 3T3 cells displayed a ligand-dependent, highly transformed phenotype. When exposed to insulinlike growth factor I or supraphysiologic levels of insulin, NIH 3T3 cells that expressed high levels of receptors formed aggregates in tissue culture dishes, colonies in soft agar,...

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Identifiers

PMID: 2153917
DOI: 10.1128/mcb.10.2.464-473.1990
PMCID: PMC360815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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