Article
Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.
Molecular and cellular biology - 1 Feb 1990
Kaleko M, Rutter W J, Miller A D
Abstract excerpt
The human insulinlike growth factor I receptor was overexpressed in NIH 3T3 cells as well as human and rat primary fibroblast strains. The NIH 3T3 cells displayed a ligand-dependent, highly transformed phenotype. When exposed to insulinlike growth factor I or supraphysiologic levels of insulin, N...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Cells, Cultured
- Flow Cytometry
- Fluorescent Antibody Technique
- Gene Expression
- Genes
- Genetic Vectors
- Humans
- Insulin
- Insulin-Like Growth Factor I
- Kinetics
- Ligands
- Mice
- Mice, Inbred Strains
- Phenotype